The Difference is Too Large for Clearing 

You need to work with overpayment and underpayment with vendors, but the system is not able to clear the open item and displays message F5263 'The difference is too large for clearing'. 
You implemented the program correction from 328245 note without success. 
Also you have customized tolerances for customer vendors, employees, and users, and accounts for cash discounts, overpayments and underpayments and clearing differences. 
Is there any different solution for this issue?

Even though you've defined the tolerance groups, it'll give that message. You are trying to enter partial payment. You should follow this process. 

1. Enter the correct data at the initial screen. 

2. When you got the open items screen, you deactivate all the items, and select only that particular item. 

3. Enter the difference amount in the difference column down right side. 

4. Save it. 

It will generate one more line item for the difference. 

See Also
SAP FI FAQ

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SAP FICO Forum - Do you have a SAP FI/CO Question?

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SAP FICO Books  - Certification, Interview Questions and Configuration

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SAP FI/CO Tips and Financial Accounting/Controlling Discussion Forum

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